Published by Business Insights
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Coverage: Global, Published: May 2009
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Kinases are a ubiquitous group of enzymes that catalyze the phosphoryl transfer reaction from a phosphate donor (usually ATP) to a receptor substrate, which can be protein, lipid, or a small molecule (e.g. sugar). Phosphorylation of protein substrates is a fundamental and reversible mechanism for regulating protein activity in eukaryotes. In addition to protein kinases, many other kinases play important roles in cellular phosphorylation reactions. Aberrant kinase activity has been directly implicated in the etiology of a wide spectrum of human pathologies. As a result of their importance, approximately 30% of current discovery and development spending focuses on kinases, especially in the fields of oncology, inflammation and metabolic diseases.

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